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It has been shown that these pathways are over-activated in diabetic hyperglycemia, leading to excessive production of ROS and causing tissue oxidative damage

d , e , Stability test of pAPCF under varying concentrations of H 2 O 2 (for d ) or GSH (for e ) by measuring the fluorescence intensity at each time point during 24 h

69,80 During aging, the level of 2-microglobulin (a component of major histocompatibility complex (MHC)-I) in plasma increases, leading to a proinflammatory phenotype in monocytes, cognitive decline, and regenerative impairments in the adult brain

Gojkovic et al., 2020), also in colitis ischemia/reperfusion (Vukojevic et al., 2018