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Activation of p21 protein can impede cellular progression from the G1 phase to the S phase, causing cellular senescence (Bourgeois and Madl, 2018)
CA: a cancer journal for clinicians
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Notably, the low dose of 1D228 at 2 mg/kg already achieved same inhibition rate of Tepotinib at 8 mg/kg (TGI, 1D228-2mg/kg/d:74.4%
