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Studies show that adequate growth hormone levels are essential for normal sleep architecture, with GH deficiency associated with sleep disturbances and reduced slow-wave sleep duration

In a multicenter study involving 68 subjects, researchers reported a positive correlation between circadian disruption and endogenous hypercortisolism [36]

This genetic variation is relatively uncommon in European populations but considerably more prevalent in some Asian populations

Since the entire retinoic acid signaling pathway seems to be dysregulated [254] and the administration of ATRA inhibited the migration of airway smooth muscle cells in vitro [255], it is possible that vitamin A supplementation reduces the abnormal migration of airway smooth muscle cells within the bronchi of asthmatic subjects