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Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ

USA 118 , (2021)

Excess glucocorticoids (GCs) can induce neuronal damage in brain regions such as the hippocampus and SN through several mechanisms, including mitochondrial dysfunction, inhibition of inhibitory and excitatory synaptic transmission, and disruption of microglial or astrocytic functions, thereby exacerbating the progression of PD ( 2.3 The close relationship between intestinal microbiota and PD In the 1980s, the first reports of Lewy body pathology in the ENS provided evidence for ENS and gut microbiota dysfunction in PD ( Lachnospira and Butyricicoccus ) and butyrate-producing [Eubacterium]_ventriosum_ group ( Proteobacteria, Verrucomicrobia, and Actinobacteria ) and five genera ( Akkermansia , Enterococcus , Hungatella , and two Ruminococcaceae ) in their gut microbiome

The most common genetic mutation (permanent alteration in the DNA sequence) that produces Gilberts syndrome occurs in an area of DNA near the UGT1A1 gene, known as promoter region, which controls the production of the UGT enzyme