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High-lipid diets may contribute to excessive lipid accumulation in hepatopancreas, necessitating increased digestive enzyme activity for efficient processing

However, in these cases, the excess glutamate comes from within the brain itself, not from the diet. There is no evidence of brain damage in humans resulting from dietary glutamate. Bottom line: Glutamate in the brain is synthesized in the brain

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5 Thus, understanding the mechanisms responsible for both advantageous and detrimental effects of MTX is crucial for identifying new targets for treatment and achieving optimal therapeutic approaches for controlling immune-mediated and inflammatory diseases while reducing detrimental adverse events related to toxicity