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All these variants are associated not only with an increased risk of developing certain types of cancers (i.e., colorectal), but also with a greater susceptibility in developing severe toxicities (grade 3) during different chemotherapy regimens, including those containing taxane

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Atherosclerosis 171:5765 Sonkusre P, Cameotra SS (2017) Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation