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Globally, 500 million to 1 billion people are affected by selenium deficiency Diets low in fresh, whole foods are often insufficient in selenium Certain conditions, including phenylketonuria , can increase the risk of deficiency Some people may also have higher needs due to inflammation, metabolic stress, or nutrient absorption issues Deficiency may go unnoticed for a while, but its effects can ripple across hormonal systems, immune regulation, and sexual vitality

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doi: 10.1038/s41392-020-00312-6 66 TakeuchiOAkiraS

Caffeine is a natural stimulant found in coffee, tea, and various other foods and has been studied for its neuroprotective role, especially in PD (152)
