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Nonn, L., et al., The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice
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Together, they extend and amplify the pituitary's natural GH pulses a mechanism with direct relevance to perimenopause, during which growth hormone declines sharply, accelerating visceral fat accumulation, muscle loss, and bone density reduction
