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Astragalin downregulates the phosphorylation level of PI3K/Akt signaling pathway-related proteins and activates autophagy in mouse hippocampal neuron HT22 cells (Wang and Tang, 2017)

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In addition, the inclusion of inhibition/activation functions to describe the oxygen-dependence on substrate consumption and on the induction of L-carnitine metabolism allowed modelling of the effect of this variable on the bioprocess [64]