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The study design and concept, as well as its ethical validity and performance, were based on the actual recommendations of the Bundesinstitut fr Arzneimittel und Medizinprodukte (BfArM) (German Federal Institute for Drugs and Medical Devices) and the Paul Ehrlich Institute, in accordance with German laws and the principles of the Declaration of Helsinki and of Good Clinical Practice

and diabetic macular edema (DME)

Biomimetic engineering techniques with immune cell membranes are now receiving more and more attention for the advantages of drug delivery 50

128 In MASLD models, SIRT1 activation elevates hepatic Treg populations and immunosuppressive cytokines such as IL-10 and TGF-, reducing hepatic inflammation