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Description
Most data comes from animal studies, a few human special-case studies, and anecdotal evidence

Transgenic mice overexpressing APP had reduced SOD1 activity in the brain
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HIF-1 deletion led to the elimination of LSCs (61), in contrast, HIF-1 deletion promoted the conversion of pre-leukemic cells to LSCs, and HIF-1 knockout in MLL-AF9 mice showed LSCs increase and AML progression after chemotherapy (62)
