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Canadian Journal of Physiology and Pharmacology

These considerations support the development of rational, multi-target strategies aimed at simultaneously limiting cardiomyocyte death and secondary inflammation, while future translational studies are needed to define safety, optimal dosing, and clinical relevance of cell deathtargeted therapies in myocardial ischemia/reperfusion injury

This has mainly derived from experimental studies, although the first results emerged over 30 years ago with the observation of reduced UA in the substantia nigra of PD patients at post mortem 10

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