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The persistence of biofilms sustains a low-level but chronic inflammatory state, releasing proteases and toxins that degrade ECM and growth factors, thereby stalling the proliferative phase of wound repair

Glutathione is also involved in restoring damaged cell components, mainly proteins and lipids of cell membranes and DNA

Inhibition of oxPPP using the inhibitors glucose-6-phosphate dehydrogenase (G6PDi) or 6-aminonicotinamide (6-AN) can suppress oxidative burst induced by various stimuli nearly as complete as direct inhibition of the NOX complex with diphenyleneiodonium chloride (DPI) (Fig