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Microglia activation is usually followed by proliferation and release of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6 [48], while there is strong evidence that this inflammatory state can lead to neuronal death in vitro and in vivo [49, 50]

Furthermore, when vitamin E reacts with lipid peroxyl radical , it leads to formation of a tocopheroxyl radical, a relatively stable, poorly reactive molecule that does not cause a new lipid peroxidation process (Table 1)

doi: 10.1093/gerona/glab327 162 OdnokozONakatsukaKWrightCCastellanosJKlichkoVIKretzschmarDet al

This finding may have implications for athletes seeking to optimize their cardiovascular performance by managing heart rate early in high-intensity efforts