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The authors have also reviewed the reference lists of key manuscripts to identify additional relevant papers

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After analyzing the effect of NR on the physiopathology and cellular mechanisms in the 3xTgAD/Pol mouse model (mice deficient in DNA repair that exacerbates the main characteristics of AD in humans) it was observed that supplementation with NR significantly increased the NAD + /NADH ratio, reduced neuroinflammation, apoptosis and damage to DNA, increased neurogenesis, restored synaptic plasticity, improved learning capacity and reversed memory deficits (Hou et al., 2017a)