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MECHANISM OF LOCAL ANESTHETIC TOXICITY Local anesthetics are generally safe and effective when limited to the site of therapy, such as tissue infiltration, near a nerve or a plexus of nerves

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Sarcoplasmic reticulum Ca 2+ release and uptake Sarcoplasmic reticulum (SR) Ca 2+ release and uptake mechanisms facilitate the majority of systolic intracellular Ca 2+ increases and diastolic decreases in the mammalian myocardium, respectively ( 2+ release channel is the cardiac ryanodine receptor (RyR2), while Ca 2+ is re-sequestered by the action of the SR Ca 2+ -ATPase (SERCA2a) ( Recent work by 2+ leak, resulting in reductions in the SR Ca 2+ content and cytosolic Ca 2+ transients

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