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J Physiol 571 (Pt 1): 5773
PTECs are highly sensitive to hyperglycemia ( Hyperglycemia increases the amount of glucose filtered through the glomeruli, thereby increasing tubular glucose load, exposure and reabsorption
Fisher rats were premedicated with subcutaneous buprenorphine (0.1 mg/kg), induced, and maintained using inhaled 2% isoflurane in oxygen at a flow rate of 100200 mL/min
