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This is the first RCT of repeated ketamine dosing in patients with TRD, in which two- and three-times weekly treatment schedules over up to 4 weeks showed comparable efficacy that was superior to placebo

Because of disturbed antioxidant abilities, UV radiation induces enhanced ROS-mediated modifications in skin cells, particularly in lipid peroxidation, resulting in increased levels of 4-hydroxynonenal (4-HNE) and prostaglandins that may act as signaling molecules [47, 87]

Systemic inflammation induces anxiety disorder through CXCL12/CXCR4 pathway

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