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At the same time, drugs also have a certain degree of side effects, such as the development of drug resistance, as well as adverse reactions to gastrointestinal symptoms, neurological and psychiatric symptoms, and other systemic symptoms

References Istituto Superiore di Sanit (2021) Dati Sorveglianza PASSI 20202021

And when the mice were simultaneously exposed to fecal transplantation from COPD patients and biomass fuel smoke for a total of 20 weeks, accelerated decline in lung function, severe emphysematous changes, airway remodeling, and excessive mucus secretion were observed (44)
