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Ageing and Parkinsons disease: substantia nigra regional selectivity

Mitochondrial synthesis begins with formation of a scaffold including two each of the proteins ISCU2, NFS1, frataxin, FDX2, ISD11, and ACP1 [108] (Figure 2)

doi: 10.1080/21655979.2021.2005931

These findings highlight a pivotal regulatory role for dopamine in iron deposition, which may be directly relevant to the iron overload and subsequent ferroptosis in SNpc dopaminergic neurons
