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A 12-week facial cream study enrolled 71 women with mild to advanced photoaging and documented increased skin density and thickness, reduced laxity, improved clarity, and reduced fine line depth
Nat Rev Dis Primers 3(1):120 da Silva L, McCray S (2009) Vitamin B12: no one should be without it

Thymidine kinase 2 gene compound heterozygous mutation leads to mitochondrial DNA depletion syndrome-2: a case report
Early reports suggest its well-tolerated, but long-term safety is still being evaluated