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Several approved painkillers are available, but current analgesics are often hampered by insufficient efficacy and/or severe adverse effects

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However, its compelling basic highlights (particular vascular effect, activation of the collateral pathways) [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41] in the most valuable animal models might still be far from the vast clinical evidence obtained in the huge number of clinical trials [1]

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