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In one study, 128 adults with low mood but not diagnosed depression were given a saffron extract (affron) at 28mg/day, 22mg/day, or a placebo for 4 weeks

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NO is synthesized from L-arginine by enzymes known as nitric oxide synthases (NOSs

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doi: 10.1016/j.biomaterials.2018.10.017 Summary Keywords chronic obstructive pulmonary disease, alveolar macrophages, macrophage polarization, immunometabolic reprogramming, immunometabolism Citation Qin Z, Liu W, Huang C and Zhang W (2025) Metabolic reprogramming of macrophages in chronic obstructive pulmonary disease

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