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Nevertheless, some oxidants including nitric oxide, peroxynitrite, and H 2 O 2 have been shown to act as second messengers, affecting a number of different signaling pathways through the oxidative modification of redox-regulated key proteins [100,101]
Extensive persistent inflammation even when SARS-CoV-2-infected cells are only sporadically present at late stages of COVID-19 (Schurink et al., 2020) could also justify low GSH levels in association with over-abundance of cellular ROS, cellular oxidative damage, increased inflammation and cell death pathways activation seen in inflammaging (Zuo et al., 2019
2020 doi: 10.1016/j.livres.2020.10.003
NNF Grant number: NNF20CC0035580, DFF and Thematic Research-Independent green research (2023): 316400026 A
