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Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy

Temperature fluctuations Consistent cold storage beats perfect temperature

Meantime, DDCu was reduced to Cu + by cellular glutathione to react with lipoylated proteins of the tricarboxylic acid cycle and destabilize the FeS cluster proteins, leading to the aggregation of dihydrolipoamide S-acetyltransferase and cuproptosis in cancer cells

Confirming the important role of the TGF/SMAD pathway in pancreatic fibrosis, we found that high glucose promoted the activation of PSCs in vitro
