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In ME/CFS patients, dysfunction of the TRPM3 calcium channel, which is critical for calcium permeability and NK cell function, results in diminished NK cell activity and disrupted calcium signaling [146]

These results underscore the critical role of adipose NAD + in modulating adaptive thermogenesis, lipolysis, and overall energy metabolism

Adequate selenium intake is mandatory for the normal function of thyrocytes, and selenium deficiency is associated with the decreased synthesis of thyroid hormones (191), increased thyroid volume, and increased number of thyroid nodules (182, 192)
