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Frontiers in Endocrinology, 12 , 767785
The presence of insulin resistance and elevated pro-inflammatory cytokines (e.g., tumor necrosis factor-) induce hepatic GH resistance (64), causing increases in GH and decreases in IGF-I levels ( Table 1 )
Conversely, traditional supplements enter, and are largely destroyed by gastric acid
The pronounced anti-aging effect of MSD-37 related to the IR extract could be linked to its higher polyphenolic concentration (151 mg GAE/mL) compared to MSD-21-IR (133.4 mg GAE/mL) and MSD-24-IR (124.2 mg GAE/mL), suggesting that increased polyphenolic content may contribute to its biological activity
