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For patients diagnosed with a vitamin B12 deficiencyespecially when caused by problems with absorption in the digestive tract (such as pernicious anemia, certain gastrointestinal conditions, or after specific surgeries)oral supplements may not be effective

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[153] showed that, when RGD was combined with adsorbed tibial proteins like fibronectin, vitronectin and fibrinogen, a markedly detrimental effect on mesenchymal stem cell (MSC) adhesion and survival was observed

In established SHIV infection in monkeys, antibody effector functions contribute to clearance of virus by nAbs but the effects are modest and enhanced FcR binding decreases rather than increases virus clearance 170,171