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Description
K.PreetiK.TonapeS.BhattacharjeeS.PatelM.ShahS
These results indicate the contribution of DA-derived quinone products along with peroxynitrite (ONOO-) and superoxide (O2-) in the inhibition of complex I and IV activities

The lag between biochemical stimulation and observable density is why early discontinuation is the most common protocol failure

A large cardiovascular outcomes trial is ongoing and expected to provide important long-term safety insights, with results anticipated around 2027
