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It has been shown that EVs derived from CRC can alter the TME, leading to tumor development and spread by promoting immune evasion and a cancerous phenotype in recipient cells (Figure 3) (Glass and Coffey, 2022)

Interestingly, and in support of our general hypothesis, there is evidence that glia - themselves organized as an interdependent syncytial network (Kalafatakis and Karagogeos, 2021

In CKD, uremic dysbiosis causes a decrease in microbial diversity, favoring the growth of pathogenic microbes that raise levels of compounds such as TMAO

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