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When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl-CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria

In sickle cell disease and thalassemia, sustained Ca 2+ influx activates scramblases and inhibits flippases, resulting in chronic phosphatidylserine exposure, procoagulant activity, and increased RBC clearance (24, 45)

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M., et al., Direct Detection of 8oxodG Using Nanopore Sequencing, Nature Communications 16, no