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For histologic analysis, mice were deeply anesthetized by intraperitoneal injection using the mixture of 40 mg/kg zolazepam/tiletamine (Zoletil 50, Virbac, Carros Cedex, France) and 5 mg/kg xylazine (Rompun, Bayer Healthcare, Leverkusen, Germany) and perfused intracardially with 0.1 M phosphate buffer (PB) containing 1000 U/ml of heparin, followed by an infusion of 4% paraformaldehyde (PFA) in 0.1 M PB

Pharmacological inhibition of NOX2 has shown promise in delaying the development of AS and reducing thrombosis in platelet-associated thrombosis [93]

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Results must always be interpreted by a knowledgeable provider who considers your full medical history and symptoms