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The key transcription factors that regulate gene expression are NF-E2-related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NF-B)

Moreover, CDK1-Cyclin B1 complex is involved in the regulation of cell cycle as an important checkpoint of G2/M phase transition [45]

The same results were observed for Akemi, Amorphous silica, and Doxorubicin in Laboratory 1, in contrast to Laboratory 2 which observed changes induced by those chemicals at high concentrations (Table 5

Even when NHP data are available, the lack of the tumor-specific antigen in this system makes these studies less translationally relevant
