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Beyond its canonical role in mediating vitamin D actions, VDR functions as a direct sensor for specific gut microbiota-derived secondary BAs, notably lithocholic acid (LCA) and its oxidized derivative 3-oxoLCA (71, 105)

SOD and CAT are key antioxidant enzymes that maintain redox balance within cells (Pudlarz et al., 2020)

Sure, they burn a little fat here and there, but most of it is based on a maladaptive second-rate carbohydrate energy system that was never contemplated in the original design prototype

The studies revealed that after 15 min at pH 7.8 with 25-fold excess BCPB and 250-fold excess of TCEP the reaction was completed with respect to thiol analytes