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The cosubstrate in the reaction is the tripeptide glutathione, which is synthesized from l-glutamic acid, cysteine, and glycine ( Figure 67 )

Mechanistically, EPA and DHA effectively reduced CUMS-induced expression of IL-1, IL-6, TNF-, microglial marker M Integrin alpha M (CD11b), and increased expression of astrocyte marker glial fibrillary acidic protein (GFAP) by regulating the NF-B/p38 signaling pathway (Yang et al., 2019)

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Cellular crosstalk during liver regeneration: unity in diversity