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187 The chemical reactivity of the epoxy-enone moiety is the basis for a postulated mechanistic link between the requirement for the 12( R )-LOX pathway of Cer-EOS metabolism and covalent binding of the ceramides (Scheme 82)

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The cost of replacing the vial is far lower than the cumulative cost of weeks of ineffective injections

The answer depends partly on reaching an effective dose, but rushing to get there creates more problems than it solves