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Ab68 may exert its anti-inflammatory effects by preventing CD38 from binding to its cognate receptor CD31, thereby reducing CD38 + immune cell adhesion to endothelium and CD31-mediated transmigration to sites of inflammation 52,56,57

The rationale is mechanistic: the two compounds operate through distinct but non-overlapping pathways, with tissue targets that complement rather than duplicate each other

European Journal of Clinical Pharmacology
