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doi: 10.1136/annrheumdis-2020-eular.4830 81

A Cochrane review summarizes the evidence and limitations

The Unflinching 'Why' Behind Refrigeration So, why the fridge

Based on researcher community reports, the most commonly noted adverse effects are injection site reactions (redness, minor discomfort), mild nausea particularly with oral administration, and occasional transient dizziness or headache

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