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As a small molecule that mimics and potentiates HGF activity while maintaining oral bioavailability and blood-brain barrier penetration, Dihexa offers practical advantages over gene therapy or protein-based approaches for clinical translation

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The NbLumSyt1-HALO/JF549 complex was then centrifuged at 18.000 g for 10 min at RT to remove precipitates, and subsequently diluted (1:200) in High K + buffer, mixed at RT for 5 min in gentle rotation (20 rpm), and used for imaging on the same day

doi: 10.3389/fbioe.2025.1582189 Received 24 February 2025 Accepted 30 June 2025 Published 14 July 2025 Volume 13 - 2025 Edited by Chun Zeng, Third Affiliated Hospital, Southern Medical University, China Reviewed by Sacha Cavelier, Queensland University of Technology, Australia Ankita Samanta, University of British Columbia, Canada Updates Copyright 2025 Nie, Liu, Zeng, Hu, Wang, Huang, Chen, Hu and Xu