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Given that IGF-1 and integrin signaling share common downstream effectors such as MAPK and Akt, we propose a model ( Figure 4 ) in bone wherein mechanical stimulation results in the activation of both IGF-1R and the integrins
Total oxidant status and oxidative stress are increased in infants with necrotizing enterocolitis
Moreover, the preservation of cell integrity via autophagy is essential for preventing neurodegeneration in dopaminergic neurons through apoptosis, involving a regulatory mechanism linked to the AKT/mTOR pathway (Zhu et al., 2024)
Free Radical Biology & Medicine 122, 116129
