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Nitrates, including GTN, can inhibit ALDH2 activity (139,140)

Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, ODay SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA, Group B-S (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation

151 Although long-term oral medications are frequently prescribed, they may cause side effects, including headache, nausea, vomiting, and possible toxicity to the liver and kidneys

Whitwell JL, Tosakulwong N, Weigand SD, Graff-Radford J, Ertekin-Taner N, Machulda MM, Duffy JR, Schwarz CG, Senjem ML, Jack CR, Lowe VJ, Josephs KA