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It has been observed that the expression level of miR-21 in the liver of diet-induced MASH mice progressively decreased with disease progression, compared with the control group (103)

doi: 10.1080/03602532.2017.1343343

doi: 10.1136/bmj-2023-076898 32 AvenellAMakJCOConnellD

In addition to mitochondrial OxS (as detailed below), there are numerous sources of endogenous OxS (e.g., inflammatory responses) that can be relevant to T2D progression [87]
