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NNMT was confirmed to be upregulated in aged versus young mouse skeletal muscle

Many provide around 66.7% of the daily value, while some contain none at all and others are fortified at extremely high doses, sometimes exceeding 5,000% and even 40,000% of the recommended intake

For example, older adults who have difficulty absorbing vitamin B12 may need a high-dose supplement to ensure adequate intake
Most older adults dont need a B12 supplement Older adults should not take B12 supplements unless they have a documented deficiency, Yourman says and only about 20 percent of adults over age 60 do, according to a report from the American Academy of Family Physicians
