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Description
RANKL binds to its receptor, namely, RANK, on osteoclast precursors and activates downstream signaling cascades, including nuclear factor kappa light chain enhancer of activated B cells (NF-B) and nuclear factor of activated T cells 1 (NFATc1), which promote precursor differentiation into mature, bone-resorbing osteoclasts and enhance their resorptive activity
Reconstitution Steps Preparation : Use sterile, bacteriostatic water, or a buffer appropriate for your research
Frequency depends on the cause of deficiency
J Physiol Paris 1993;87(5):313-327
