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Although patients feel thirsty, and increase their fluid consumption, this doesnt effectively decrease the solute concentration in their blood because ADH levels are not high enough to trigger water reabsorption in the kidneys

As a result of overexpression GGCT, not only did the level of glutamate m + 5 decrease, but also the levels of downstream metabolites such as -KG m + 5, succinate m + 4, fumarate m + 4 and malate m + 4 in the TCA cycle were affected (Fig

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