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Our data provide another possible mechanism for this phenomenon, that enzymatic activity and/or protein-metabolite binding kinetics may account for time-dependent compound signal drift

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J Agric Food Chem 66:11911196 Pan H-Y, Ye Z-W, Zheng Q-W, Yun F, Tu M-Z, Hong W-G, Chen B-X, Guo L-Q, Lin J-F (2022) Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation