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By analysing cf-mtDNA levels in the tear fluid, mitochondrial damage and impairments can be detected early at the stage of reversible damage to health, which is crucial for tailoring preventive measures and individualised treatments [36, 66, 71, 72]

[DOI] [PMC free article] [PubMed] [Google Scholar] 100.George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, ORahilly S, Barroso I

43 Another meta-analysis also reported that TMAO may be a novel biomarker for DM