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The establishment of the mitochondrial membrane potential is an essential component in the generation of ATP during oxidative phosphorylation

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Critically, altered Ca 2+ clearance mechanisms of mitochondrial uptake amplify this dysregulation ( 2+ -ATPases (PMCA), mainly PMCA1 (ATP2B1) and PMCA4 (ATP2B4) are responsible for restoring basal cytosolic Ca 2+ levels following platelet activation (Millington-Burgess and Harper, 2021)

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