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Gasdermin E deletion attenuates ureteral obstruction- and 5/6 nephrectomy-induced renal fibrosis and kidney dysfunction

Dihexa (full name: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is technically a peptidomimetica small molecule designed to mimic peptide binding activity while having improved stability and bioavailability compared to peptides

From March 1 to August 19, 2019, the study included a total of 706 subjects, who were randomly assigned to the drug group or the placebo group in a 6:1 ratio: Subcutaneous injection of cagrilintide once a week, divided into 5 dose groups (0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg): 100-102 people in each group

Recently, Masuda et al