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Description
Simnick, M.R

The influence of circadian rhythm on metabolic homeostasis, neuroendocrine signaling, immune and oxidative stress responses, tissue repair and autophagy activity is orchestrated by a group of clock genes, with Bmal1 serving as the central regulator

Int J Mol Sci (2020) 22:330

[183] showed that HRS reduces apoptosis induced by skin I/R and improves flap survival modulation of the Bax/Bcl2 ratio and inhibition of the activated Apoptosis SignalRegulating Kinase 1/JNK pathway
